Microbiology and Immunology Discipline

Center for Cancer Cell Biology, Immunology, and Infection

Fabio Re graduated from the University of Milan in 1989. In the lab of Dr. Alberto Mantovani at the Mario Negri Institute for Pharmacological Research he conducted studies on the role of the Interleukin-1 receptor that led to the concept of “decoy receptor”, a paradigm later found to apply to other cytokine systems.

As a postdoctoral fellow at Columbia University, New York, in the lab of Dr. Jeremy Luban he studied the effect of HIV infection on cell cycle progression.

In 1999 he joined the lab of Dr. Jack Strominger at the Dana-Farber Cancer Institute, Boston, where he studied several aspects of the biology of toll-like receptors (TLR). During this period he held an Instructor position in the Department of Pathology of the Harvard University Medical School.

In 2004 he was appointed Assistant Professor in the Department of Molecular Sciences at the University of Tennessee Health Science Center in Memphis. His research efforts remained focused on innate immunity. He was tenured and promoted to Associate Professor in 2010.

In 2012 he joined the faculty of Chicago Medical School at ÎÞÂëȺ½» of Medicine and Science as Associate Professor (with Tenure) of Microbiology and Immunology, and he was promoted to Professor in 2019.

Research Interests

Our lab studies the interaction of the host with pathogens and commensals. We focus our attention on inflammation and innate immune pathways activated in response to infection or vaccination. Particular attention is devoted to Toll-like receptors (TLR) and Nod-like receptors (NLR), the tissue injury caused by unrestrained neutrophils activation, and the role of “innate” B1 B cells. These processes are investigated using animal models of bacterial and viral infections (Francisella tularensis, Burkholderia thailandensis, MHV coronavirus). 

Re Lab Protocols

Publications

See his publication history here: