Dr. Kelly Oh received her PhD from the department of Cellular and Molecular Biology, Roswell Park Cancer Institute, SUNY at Buffalo in 1999.  She was a post-doctoral researcher at University of California at San Francisco from 1999 to 2007 and a senior scientist at Applied Biomics (Hayward, CA) from 2007 to 2008.  She joined the ÎÞÂëȺ½» faculty in 2008 as a Research Assistant Professor of Cell Biology and Anatomy.

Research

The primary pathogenic event in Duchenne Muscular Dystrophy is muscle cell necrosis, which is followed by regenerative responses. We found that the loss of dystrophin in C. elegans causes a progressive muscle cell death as in mammals, and that the muscle cell death can be prevented by modulating signaling pathways. Currently, we are investigating roles of IGF-1 signaling and stress responses in dystrophic muscle cells.

Publications

Articles were published under the name of Hyun Ju Oh until 2011

Oh KH and Kim H Aging 5(12):865-6, 2013

Oh KH and Kim H Proc Natl Acad Sci U S A. Nov 19;110(47):19024-9, 2013

Sancar F, Touroutine D, Gao S, Oh HJ, Gendrel M, Bessereau JL, Kim H, Zhen M, Richmond JE.

Journal of Biological Chemistry 286(38):33501-10, 2011

Abraham LS, Oh HJ, Sancar F., Richmond JE and Kim H. An alpha-catulin homologue controls neuromuscular function through localization of the dystrophin complex and BK channels in Caenorhabditis elegans PLoS Genetics  6(8). pii: e1001077, 2010 (Equal contribution first author)

Kim H, Pierce-Shimomura JT, Oh HJ, Johnson BE, Goodman MB, McIntire SL  PLoS Genet. 5(12):e1000780, 2009

Peng H, Psulkowski ED, Gibson LC, Ivanov AV, Oh HJ, Lau Y-FC, and Rauscher III FJ.  A KRAB domain recruits the KAP1 silencing machinery to SRY and functions in gonad differentiation and sex determination. Journal of Biological Chemistry 284(51):35670-80, 2009

Oh HJ, Kido T and Lau Y.-F.C   PIAS1 represses SOX9 activity by a mechanism independent of its SUMO-ligase function for SOX9. Molecular Reproduction and Development 74(11):1446-55, 2007

Li Y., Oh HJ and Lau Y.-F.C.  The Poly (ADP-ribose) Polymerase 1 interacts with Sry and modulates its biological function. Molecular and Cellular Endocrinology 257-258: 35-46, 2006

Oh HJ and Lau Y.-.F. C.  KRAB: A partner for SRY action on chromatin Molecular and Cellular Endocrinology 247, 47-52, 2006

Oh HJ, Li Y. and Lau Y.-F. C.  The mouse Sry interacts with a protein containing the Krueppel-Associated Box (KRAB) domain.  Biology of Reproduction 72(2), 407-415, 2005

Wang XY, Chen X, Oh HJ, Repasky E, Kazim L and Subjeck J Characterization of native interaction of hsp110 with hsp25 and hsc70. FEBS Lett. 465, 98-102, 2000

Henics T, Nagy E, Oh HJ, Csermely P, von Gabain A and Subjeck JR  Mammalian Hsp70 and Hsp110 proteins bind to RNA motifs involved in mRNA stability. Journal of Biological Chemistry.274,17318-17324, 1999

Oh HJ, Easton D, Murrawski M, Kaneko Y and John R. Subjeck. The chaperoning activity of hsp110: Identification of functional domains by use of targeted deletions. Journal of Biological Chemistry.274,15712-15718, 1999

Oh HJ, Xing Chen, and John R. Subjeck. Hsp110 protects heat-denatured proteins and confers cellular thermoresistance. Journal of Biological Chemistry. 272, 31636-31640, 1997

Xing Chen, Douglas Easton, Oh HJ, Dong-Sin Lee-Yoon, Xiaoguang Liu, and John Subjeck.  The 170 Kda glucose regulated stress protein is a large HSP70-, HSP110-like protein of the endoplasmic reticulum. FEBS Letters 380, 68-72, 1996